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Article

Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population.

Neuropsychobiology - 1 Jan 2006

Nishizawa Daisuke, Han Wenhua, Hasegawa Junko, Ishida Takafumi, Numata Yukio, Sato Tadahiro, Kawai Atsuko, Ikeda Kazutaka

Abstract excerpt

Ethanol is considered to activate the brain reward system by increasing the release of an endogenous opioid receptor ligand, beta-endorphin. The polymorphism A118G in the mu-opioid receptor gene (OPRM1) causes the amino acid change Asn40Asp and has been reported to affect the affinity of the ligand for the receptor. The association of this polymorphism with the vulnerability to alcohol dependence has been studied...

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Source

Identifiers

PMID: 16679777
DOI: 10.1159/000093099

Genes

OPRM1
ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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