Article
Pharmacogenetics of opioid receptors and addiction.
Pharmacogenetics and genomics - 1 Jan 2006
Mayer Peter, Höllt Volker
Abstract excerpt
It is generally assumed that combinations of polymorphic alleles of different genes contribute to polygenetic disorders. Variants of the opioid receptors are the obvious candidates underlying addiction. Most research has focused on the coding variation A118G of the mu opioid receptor (MOPr), which replaces asparagine at position 40 by aspartate (Asn40Asp). However, to date, no conclusive evidence exists regarding...
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