Article
The geographic spread of the CCR5 Delta32 HIV-resistance allele.
PLoS biology - 1 Nov 2005
Novembre John, Galvani Alison P, Slatkin Montgomery
Abstract excerpt
The Delta32 mutation at the CCR5 locus is a well-studied example of natural selection acting in humans. The mutation is found principally in Europe and western Asia, with higher frequencies generally in the north. Homozygous carriers of the Delta32 mutation are resistant to HIV-1 infection because the mutation prevents functional expression of the CCR5 chemokine receptor normally used by HIV-1 to enter CD4+ T...
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