Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The histone acetyltransferase domains of CREB-binding protein (CBP) and p300/CBP-associated factor are not necessary for cooperativity with the class II transactivator.

The Journal of biological chemistry - 19 Oct 2001

Harton J A, Zika E, Ting J P

Abstract excerpt

The class II transactivator (CIITA) is a transcriptional co-activator regulating the constitutive and interferon-gamma-inducible expression of class II major histocompatibility complex (MHC) and related genes. Promoter remodeling occurs following CIITA induction, suggesting the involvement of chromatin remodeling factors. Transcription of numerous genes requires the histone acetyltransferase (HAT) activities of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyltransferases
Share to COS Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CREB-Binding Protein

Share to Histone Acetyltransferases

Share to Lysine

Share to Microscopy, Fluorescence

Share to Trans-Activators

Share to Transcriptional Activation

Source

Identifiers

PMID: 11514574
DOI: 10.1074/jbc.M106652200

Genes

CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The histone acetyltransferase domains of CREB-binding protein (CBP) and p300/CBP-associated factor are not necessary for cooperativity with the class II transactivator.PMID 11514574Read ↗

Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes.Semantic proximity Read ↗

Is histone acetylation the most important physiological function for CBP and p300?Semantic proximity Read ↗

Nuclear Factor of Activated T Cells (NFAT)-dependent Transactivation Regulated by the Coactivators p300/CREB-binding Protein (CBP)Semantic proximity Read ↗

CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation.Semantic proximity Read ↗

Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity.Semantic proximity Read ↗

Self-association of CIITA and its transactivation potential.Semantic proximity Read ↗

p300/CBP proteins: HATs for transcriptional bridges and scaffoldsSemantic proximity Read ↗

Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.Semantic proximity Read ↗

Differential use of CREB binding protein-coactivator complexes.Semantic proximity Read ↗

Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development.Semantic proximity Read ↗

Acetylation of importin-alpha nuclear import factors by CBP/p300.Semantic proximity Read ↗

Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.