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Article

Differential use of CREB binding protein-coactivator complexes.

Science (New York, N.Y.) - 30 Jan 1998

Kurokawa R, Kalafus D, Ogliastro M H, Kioussi C, Xu L, Torchia J, Rosenfeld M G, Glass C K

Abstract excerpt

CREB binding protein (CBP) functions as an essential coactivator of transcription factors that are inhibited by the adenovirus early gene product E1A. Transcriptional activation by the signal transducer and activator of transcription-1 (STAT1) protein requires the C/H3 domain in CBP, which is the primary target of E1A inhibition. Here it was found that the C/H3 domain is not required for retinoic acid receptor...

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Identifiers

PMID: 9445474
DOI: 10.1126/science.279.5351.700

Genes

STAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Differential use of CREB binding protein-coactivator complexes.PMID 9445474Read ↗

Transcription factor-specific requirements for coactivators and their acetyltransferase functions.Semantic proximity Read ↗

E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivatorsSemantic proximity Read ↗

Differential regulation of three members of the ATF/CREB family of DNA-binding proteins.Semantic proximity Read ↗

CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation.Semantic proximity Read ↗

Nuclear Factor of Activated T Cells (NFAT)-dependent Transactivation Regulated by the Coactivators p300/CREB-binding Protein (CBP)Semantic proximity Read ↗

Transcriptional Co-activators CREB-binding protein/p300 increase chondrocyte Cd-rap gene expression by multiple mechanisms including sequestration of the repressor CCAAT/enhancer-binding protein.Semantic proximity Read ↗

The transcriptional co-activator proteins p300 and CBP stimulate adenovirus E1A conserved region 1 transactivation independent of a direct interaction.Semantic proximity Read ↗

Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP.Semantic proximity Read ↗

Extracellular signals regulate rapid coactivator recruitment at AP-1 sites by altered phosphorylation of both CREB binding protein and c-jun.Semantic proximity Read ↗

Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domainsSemantic proximity Read ↗

A genetic screen identifies putative targets and binding partners of CREB-binding protein in the developing Drosophila eye.Semantic proximity Read ↗

Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter.Semantic proximity Read ↗

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