Mice deficient for the CD40 ligand.

doi:10.1016/1074-7613(94)90073-6

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Article

Mice deficient for the CD40 ligand.

Immunity - 1 Aug 1994

Xu J, Foy T M, Laman J D, Elliott E A, Dunn J J, Waldschmidt T J, Elsemore J, Noelle R J, Flavell R A

Abstract excerpt

To study the potential roles of CD40L in immune responses, we generated CD40L-deficient mice by gene targeting. Similar to the effects of CD40L mutations in humans (hyper-IgM syndrome), CD40L-deficient mice have a decreased IgM response to thymus-dependent antigens, fail altogether to produce an...

Topics

Animals
Antibody Formation
B-Lymphocytes
CD40 Ligand
Disease Models, Animal
Female
Gene Targeting
Hypergammaglobulinemia
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Immunologic Memory
Male
Membrane Glycoproteins
Mice
Mice, Mutant Strains
Phenotype
Thymus Gland

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