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Article

Technical note: linkage disequilibrium and disease-associated CTLA4 gene polymorphisms.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2001

Holopainen P M, Partanen J A

Abstract excerpt

CTLA4 and CD28 are important regulators of T lymphocyte activation. Gene region 2q33 carrying genes for both CTLA4 and CD28 has been shown to be linked to many autoimmune diseases. Disease associations with particular CTLA4 gene polymorphisms have been reported. Recently, first lines of evidence emerged for functional effects of CTLA4 gene polymorphisms. Two independent studies reported a reduced inhibitory...

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Source

Identifiers

PMID: 11509583
DOI: 10.4049/jimmunol.167.5.2457

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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