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Article

CD28, CTLA-4 and CCL5 gene polymorphisms in patients with rheumatoid arthritis.

Clinical rheumatology - 1 May 2017

Luterek-Puszyńska Katarzyna, Malinowski Damian, Paradowska-Gorycka Agnieszka, Safranow Krzysztof, Pawlik Andrzej

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint destruction caused by infiltrating leukocytes including T cells. An important role in T cell co-stimulation is played by the CD28, as a stimulatory signal transducer and the inhibitory CTLA-4. CCL5 is produced by circulating T cells and plays an active role in the chemotactic activity of T cells in RA. The aim of this study was to...

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Source

Identifiers

PMID: 27988812
DOI: 10.1007/s10067-016-3496-2

Genes

CCL5
CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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