Article
CTLA-4/CD 28 region polymorphisms in children from families with autoimmune hepatitis.
Human immunology - 1 Dec 2001
Djilali-Saiah I, Ouellette P, Caillat-Zucman S, Debray D, Kohn J I, Alvarez F
Abstract excerpt
Susceptibility to autoimmune hepatitis is associated with particular human leucocyte antigen class II alleles. However, non-HLA genetic factors are likely to be required for development of the disease. Among the candidate genes, the cytotoxic T-lymphocyte antigen 4 (CTLA-4) and CD28 genes, located on chromosome 2q33 in humans, encode a cell surface molecule playing a dominant role in the regulation of T-cell...
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