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Article

Influence of CTLA-4 gene polymorphism in autoimmune and infectious diseases.

Human immunology - 1 Jul 2009

Fernández-Mestre Mercedes, Sánchez Karen, Balbás Omar, Gendzekhzadze Ketevan, Ogando Violeta, Cabrera Mayra, Layrisse Zulay

Abstract excerpt

Cell-mediated immunity requires costimulatory activity to initiate or inhibit antigen-specific T-cell responses. CTLA-4 is an inhibitory receptor expressed by activated and regulatory T cells. The single nucleotide polymorphism (SNP) +49 A/G of the CTLA-4 gene alters intracellular distribution of CTLA-4, interleukin-2 production, and, as a consequence, T-cell proliferation. The aim of this study was to analyze...

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Source

Identifiers

PMID: 19345707
DOI: 10.1016/j.humimm.2009.03.016

Genes

CTLA4
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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