Article
Temperature-dependent regulation of a heterologous transcriptional activation domain fused to yeast heat shock transcription factor.
Molecular and cellular biology - 1 Mar 1992
Bonner J J, Heyward S, Fackenthal D L
Abstract excerpt
The heat shock transcription factor (HSF) of the yeast Saccharomyces cerevisiae is posttranslationally modified. At low growth temperatures, it activates transcription of heat shock genes only poorly; after shift to high temperatures, it activates transcription readily. In an effort to elucidate the mechanism of this regulation, we constructed a series of HSF-VP16 fusions that join the HSF DNA-binding domain to...
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