Article
A new strain of rat for functional analysis of PINA.
Brain research. Molecular brain research - 13 Jun 2005
Ahmed Samreen, Deng Jie, Borjigin Jimo
Abstract excerpt
Long Evans cinnamon (LEC) rat is an animal model for human Wilson disease (WD) due to a deletion in Atp7b, the copper transporter defective in WD patients. Previously, we have demonstrated presence of an alternative product termed PIneal Night-specific ATPase (PINA) generated by an intronic promoter in Atp7b gene. Analysis of LEC rat in this study demonstrates that PINA is absent in the LEC pineal establishing...
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