Article
The role of neutral sphingomyelinase in interleukin-1beta signal transduction in mouse cerebral cortex cells.
Neuroscience and behavioral physiology - 1 Jan 2000
Rybakina E G, Nalivaeva N N, Pivanovich Y U, Shanin S N, Kozinets A, Korneva E A
Abstract excerpt
The cytokine interleukin-1 (IL-1) is an important mediator of neuroimmune interactions, though it has not been established precisely how the IL-lbeta signal is transmitted in nerve cells. This study demonstrates the involvement of the sphingomyelin cascade in IL-1beta signal transduction in the P2 membrane fraction of the mouse cerebral cortex. The key role of the membrane enzyme neutral sphingomyelinase in...
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