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Article

Ceramide mediates the rapid phase of febrile response to IL-1beta.

Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2006

Sanchez-Alavez Manuel, Tabarean Iustin V, Behrens M Margarita, Bartfai Tamas

Abstract excerpt

IL-1beta was identified after a long search for the endogenous pyrogen. It acts by inducing synthesis of prostaglandin E2, which mediates the late phase of IL-1beta-induced fever. Here we show by radiotelemetry that the early phase of the fever response to IL-1beta is mediated by ceramide. Hypothalamic application of the cell-penetrating C2-ceramide mimics the rapid phase of the IL-1beta-induced fever. Inhibition...

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Identifiers

PMID: 16477014
DOI: 10.1073/pnas.0510960103
PMCID: PMC1413811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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