Article
Association and aggregation analysis using kin-cohort designs with applications to genotype and family history data from the Washington Ashkenazi Study.
Genetic epidemiology - 1 Sept 2001
Chatterjee N, Shih J, Hartge P, Brody L, Tucker M, Wacholder S
Abstract excerpt
When a rare inherited mutation in a disease gene, such as BRCA1, is found through extensive study of high-risk families, it is critical to estimate not only age-specific penetrance of the disease associated with the mutation, but also the residual effect of family history once the mutation is taken into account. The kin-cohort design, a cross-sectional survey of a suitable population that collects DNA and family...
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