Article
A marginal likelihood approach for estimating penetrance from kin-cohort designs.
Biometrics - 1 Mar 2001
Chatterjee N, Wacholder S
Abstract excerpt
The kin-cohort design is a promising alternative to traditional cohort or case-control designs for estimating penetrance of an identified rare autosomal mutation. In this design, a suitably selected sample of participants provides genotype and detailed family history information on the disease of interest. To estimate penetrance of the mutation, we consider a marginal likelihood approach that is computationally...
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