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Article

Kin-cohort designs for gene characterization.

Journal of the National Cancer Institute. Monographs - 1 Jan 1999

Gail M H, Pee D, Carroll R

Abstract excerpt

BACKGROUND: In the kin-cohort design, a volunteer with or without disease (the proband) agrees to be genotyped, and one obtains information on the history of a disease in first-degree relatives of the proband. From these data, one can estimate the penetrance of an autosomal dominant gene, and this technique has been used to estimate the probability that Ashkenazi Jewish women with specific mutations of BRCA1 or...

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Identifiers

PMID: 10854487
DOI: 10.1093/oxfordjournals.jncimonographs.a024227

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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