Article
Pseudo-likelihood estimates of the cumulative risk of an autosomal dominant disease from a kin-cohort study.
Genetic epidemiology - 1 Feb 2001
Moore D F, Chatterjee N, Pee D, Gail M H
Abstract excerpt
Wacholder et al. [1998: Am J Epidemiol 148:623-629] and Struewing et al. [1997: N Engl J Med 336:1401-1408] have recently proposed a design called the kin-cohort design to estimate the probability of developing disease (penetrance) associated with an autosomal dominant gene. In this design, volunteers (probands) agree to be genotyped and one also determines the disease history (phenotype) of first-degree...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.