Article
A weighted cohort approach for analysing factors modifying disease risks in carriers of high-risk susceptibility genes.
Genetic epidemiology - 1 Jul 2005
Antoniou Antonis C, Goldgar David E, Andrieu Nadine, Chang-Claude Jenny, Brohet Richard, Rookus Matti A, Easton Douglas F
Abstract excerpt
The authors propose a novel approach to evaluate the effects of risk factors on disease risks in carriers of high-penetrance alleles in disease susceptibility genes. Most studies to date have utilised data collected on carriers identified through ongoing genetic testing programs. The advantage of this approach is that it allows relatively large numbers of affected and unaffected carriers to be identified rapidly....
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