Article
A unified model for estimating and testing familial aggregation.
Statistics in medicine - 30 Dec 2013
Lee Myeongjee, Rebora Paola, Valsecchi Maria Grazia, Czene Kamila, Reilly Marie
Abstract excerpt
Investigations of familial aggregation of disease can provide important clues for genetic mechanisms, and many such studies have been published in the epidemiological literature using various statistical methods. We developed a unified model for familial risk by extending a Cox regression model to enable estimation of the detailed effects of kinship. By appropriate parameterisation of the model, we show how the...
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