Case-control and case-only designs with genotype and family history data: estimating relative risk, residual familial aggregation, and cumulative risk.

Abstract excerpt

In case-control studies of inherited diseases, participating subjects (probands) are often interviewed to collect detailed data about disease history and age-at-onset information in their family members. Genotype data are typically collected from the probands, but not from their relatives. In this article, we introduce an approach that combines case-control analysis of data on the probands with kin-cohort...

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