Article
Ryanodine sensitizes the Ca(2+) release channel (ryanodine receptor) to Ca(2+) activation.
The Journal of biological chemistry - 26 Oct 2001
Masumiya H, Li P, Zhang L, Chen S R
Abstract excerpt
Ryanodine, a plant alkaloid, is one of the most widely used pharmacological probes for intracellular Ca(2+) signaling in a variety of muscle and non-muscle cells. Upon binding to the Ca(2+) release channel (ryanodine receptor), ryanodine causes two major changes in the channel: a reduction in single-channel conductance and a marked increase in open probability. The molecular mechanisms underlying these...
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