Article
Enhanced basal activity of a cardiac Ca2+ release channel (ryanodine receptor) mutant associated with ventricular tachycardia and sudden death.
Circulation research - 9 Aug 2002
Jiang Dawei, Xiao Bailong, Zhang Lin, Chen S R Wayne
Abstract excerpt
Mutations in the human cardiac Ca2+ release channel (ryanodine receptor, RyR2) gene have recently been shown to cause effort-induced ventricular arrhythmias. However, the consequences of these disease-causing mutations in RyR2 channel function are unknown. In the present study, we characterized the properties of mutation R4496C of mouse RyR2, which is equivalent to a disease-causing human RyR2 mutation R4497C, by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.