Ryanodine receptor as a new therapeutic target of heart failure and lethal arrhythmia.

Abstract excerpt

Abnormal intracellular Ca(2+) handling by the sarcoplasmic reticulum (SR) is a critical factor in the development of heart failure (HF). Not only decreased Ca(2+) uptake, but also uncoordinated Ca(2+) release plays a significant role in contractile and relaxation dysfunction. Spontaneous Ca(2+) release through ryanodine receptor (RyR) 2, a huge tetrameric protein, during diastole leads to a decrease in the SR...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Arrhythmias, Cardiac
• Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2