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Article

Molecular identification of the ryanodine receptor Ca2+ sensor.

The Journal of biological chemistry - 12 Jun 1998

Chen S R, Ebisawa K, Li X, Zhang L

Abstract excerpt

We have investigated the molecular basis for ryanodine receptor (RyR) activation by Ca2+ by using site-directed mutagenesis together with functional assays consisting of Ca2+ release measurements and single channel recordings in planar lipid bilayers. We report here that a single substitution of alanine for glutamate at position 3885 (located in the putative transmembrane sequence M2 of the type 3 RyR) reduces...

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Identifiers

PMID: 9614063
DOI: 10.1074/jbc.273.24.14675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular identification of the ryanodine receptor Ca2+ sensor.PMID 9614063Read ↗

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