Article
The ryanodine receptor: a pivotal Ca2+ regulatory protein and potential therapeutic drug target.
Current drug targets - 1 May 2011
Dulhunty Angela F, Casarotto Marco G, Beard Nicole A
Abstract excerpt
The ryanodine receptor (RyR) calcium release channel is an essential intracellular ion channel that is central to Ca(2+) signaling and contraction in the heart and skeletal muscle. The rapid release of Ca(2+) from the internal sarcoplasmic reticulum Ca(2+) stores through the RyR during excitation-contraction coupling is facilitated by the unique arrangement of the surface and sarcoplasmic reticulum membrane...
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