Article
The EF-hand Ca2+ Binding Domain Is Not Required for Cytosolic Ca2+ Activation of the Cardiac Ryanodine Receptor.
The Journal of biological chemistry - 29 Jan 2016
Guo Wenting, Sun Bo, Xiao Zhichao, Liu Yingjie, Wang Yundi, Zhang Lin, Wang Ruiwu, Chen S R Wayne
Abstract excerpt
Activation of the cardiac ryanodine receptor (RyR2) by elevating cytosolic Ca(2+) is a central step in the process of Ca(2+)-induced Ca(2+) release, but the molecular basis of RyR2 activation by cytosolic Ca(2+) is poorly defined. It has been proposed recently that the putative Ca(2+) binding domain encompassing a pair of EF-hand motifs (EF1 and EF2) in the skeletal muscle ryanodine receptor (RyR1) functions as a...
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