Article
Association of common missense changes in ELAC2 ( HPC2) with prostate cancer in a Japanese case-control series.
Journal of human genetics - 1 Jan 2002
Fujiwara Hiromichi, Emi Mitsura, Nagai Hisaki, Nishimura Taiji, Konishi Noboru, Kubota Yoshinobu, Ichikawa Tomohiko, Takahashi Satoru, Shuin Taro, Habuchi Tomonori, Ogawa Osamu, Inoue Katsuki, Skolnick Mark H, Swensen Jeff, Camp Nicola J, Tavtigian Sean V
Abstract excerpt
The recently identified prostate cancer susceptibility gene ELAC2 ( HPC2) harbors two common missense variants, a serine to leucine substitution at residue 217 (Leu217) and an alanine to threonine substitution at residue 541 (Thr541). We genotyped the two variants in a Japanese cohort consisting of 350 prostate cancer patients 242 male population controls, and 114 male low-risk controls. Both missense alleles,...
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