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Article

Pharmacogenomics of maternal tobacco use: metabolic gene polymorphisms and risk of adverse pregnancy outcomes.

Obstetrics and gynecology - 1 Mar 2010

Aagaard-Tillery Kjersti, Spong Catherine Y, Thom Elizabeth, Sibai Baha, Wendel George, Wenstrom Katharine, Samuels Philip, Simhan Hyagriv, Sorokin Yoram, Miodovnik Menachem, Meis Paul, O'Sullivan Mary J, Conway Deborah, Wapner Ronald J

Abstract excerpt

OBJECTIVE: To assess whether functional maternal or fetal genotypes along well-characterized metabolic pathways (ie, CYP1A1, GSTT1, and CYP2A6) may account for varying associations with adverse outcomes among pregnant women who smoke. METHODS: DNA samples from 502 smokers and their conceptuses, alongside women in a control group, were genotyped for known functional allelic variants of CYP1A1 (Ile462Val AA>AG/GG),...

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Share to Aryl Hydrocarbon Hydroxylases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20177288
DOI: 10.1097/AOG.0b013e3181d06faf
PMCID: PMC3263385

Genes

GSTT1

Provenance

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