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Article

G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease.

American journal of physiology. Lung cellular and molecular physiology - 1 Sept 2001

McMorran B J, Palmer J S, Lunn D P, Oceandy D, Costelloe E O, Thomas G R, Hume D A, Wainwright B J

Abstract excerpt

Several cystic fibrosis (CF) mouse models demonstrate an increased susceptibility to Pseudomonas aeruginosa lung infection, characterized by excessive inflammation and high rates of mortality. Here we developed a model of chronic P. aeruginosa lung disease in mice homozygous for the murine CF transmembrane conductance regulator G551D mutation that provides an excellent model for CF lung disease. After 3 days of...

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Identifiers

PMID: 11504703
DOI: 10.1152/ajplung.2001.281.3.L740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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