Article
Role of Cftr genotype in the response to chronic Pseudomonas aeruginosa lung infection in mice.
American journal of physiology. Lung cellular and molecular physiology - 1 Nov 2004
van Heeckeren Anna M, Schluchter Mark D, Drumm Mitchell L, Davis Pamela B
Abstract excerpt
Patients with cystic fibrosis have a lesion in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which is associated with abnormal regulation of other ion channels, abnormal glycosylation of secreted and cell surface molecules, and vulnerability to bacterial infection and inflammation in the lung usually leading to the death of these patients. The exact mechanism(s) by which mutation in CFTR...
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