Article
Mouse models of cystic fibrosis: phenotypic analysis and research applications.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jun 2011
Wilke Martina, Buijs-Offerman Ruvalic M, Aarbiou Jamil, Colledge William H, Sheppard David N, Touqui Lhousseine, Bot Alice, Jorna Huub, de Jonge Hugo R, Scholte Bob J
Abstract excerpt
Genetically modified mice have been studied for more than fifteen years as models of cystic fibrosis (CF). The large amount of experimental data generated illuminates the complex multi-organ pathology of CF and raises new questions relevant to human disease. CF mice have also been used to test experimental therapies prior to clinical trials. This review recapitulates the major phenotypic traits of CF mice and...
Topics
- Animals
- Biomedical Research
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Disease Models, Animal
- Humans
- Mice
- Mice, Inbred CFTR
- Mice, Mutant Strains
- Phenotype