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Article

Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities.

Human molecular genetics - 1 May 2002

Oceandy Delvac, McMorran Brendan J, Smith Stephen N, Schreiber Rainer, Kunzelmann Karl, Alton Eric W F W, Hume David A, Wainwright Brandon J

Abstract excerpt

Increasingly, cystic fibrosis (CF) is regarded as an inflammatory disorder where the response of the lung to Pseudomonas aeruginosa is exaggerated as a consequence of processes mediated by the product of the CF gene, CFTR. Of importance to any gene-replacement strategy for treatment of CF is the...

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Source

Identifiers

PMID: 11978765
DOI: 10.1093/hmg/11.9.1059

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11978765-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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