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A chronic <i>Pseudomonas aeruginosa</i> mouse lung infection modeling the pathophysiology and inflammation of human cystic fibrosis

2024-10-07

Abstract excerpt

Investigation of chronic cystic fibrosis (CF) lung infections has been limited by a lack of murine models that reproduce obstructive lung pathology, chronicity of bacterial infections, and complex inflammation in human CF lung pathology. Three different approaches have been used separately to address these limitations, including using transgenic Scnn1b-Tg mice overexpressing a lung epithelial sodium channel to mi...

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Literature Corpus work
06786343-c570-5c62-b900-46da024a9a71
DOI
10.1101/2024.10.07.617039
Open publication

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