Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mutant of SWAP-70, a phosphatidylinositoltrisphosphate binding protein, transforms mouse embryo fibroblasts, which is inhibited by sanguinarine.

PloS one - 2 Dec 2010

Fukui Yasuhisa, Ihara Sayoko

Abstract excerpt

SWAP-70, a phosphatidylinositol trisphosphate (PtdIns(3,4,5)P(3)) binding protein, has been suggested to be involved in transformation of mouse embryo fibroblasts (MEFs) as well as membrane ruffling after growth factor stimulation of the cells. A mutant, SWAP-70-374, was found to be able to bind...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Chlorocebus aethiops
Share to COS Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Isoquinolines

Share to Microscopy, Confocal

Share to Minor Histocompatibility Antigens

Share to Phosphatidylinositol Phosphates

Source

Open in PubMed Open full text

Identifiers

PMID: 21152038
DOI: 10.1371/journal.pone.0014180
PMCID: PMC2996291

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21152038-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mutant of SWAP-70, a phosphatidylinositoltrisphosphate binding protein, transforms mouse embryo fibroblasts, which is inhibited by sanguinarine.PMID 21152038Read ↗

SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling.Semantic proximity Read ↗

SWAP-70 contributes to spontaneous transformation of mouse embryo fibroblasts.Semantic proximity Read ↗

SWAP-70 is important for invasive phenotypes of mouse embryo fibroblasts transformed by v-Src.Semantic proximity Read ↗

SWAP-70: a new type of oncogene.Semantic proximity Read ↗

SWAP-70 identifies a transitional subset of actin filaments in motile cells.Semantic proximity Read ↗

SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration.Semantic proximity Read ↗

Impaired IgE response in SWAP-70-deficient mice.Semantic proximity Read ↗

Swap70b is required for convergent and extension cell movement during zebrafish gastrulation linking Wnt11 signalling and RhoA effector function.Semantic proximity Read ↗

Conversion of PtdIns(4,5)P2 into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphologySemantic proximity Read ↗

Phosphatidylinositol 4-Kinase IIIβ Is Required for Severe Acute Respiratory Syndrome Coronavirus Spike-mediated Cell EntrySemantic proximity Read ↗

Studies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinase.Semantic proximity Read ↗

Scapinin, the protein phosphatase 1 binding protein, enhances cell spreading and motility by interacting with the actin cytoskeleton.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.