Article
Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency.
Clinical immunology (Orlando, Fla.) - 1 Dec 2001
Rapalus L, Minegishi Y, Lavoie A, Cunningham-Rundles C, Conley M E
Abstract excerpt
SWAP-70 is a recently identified protein that functions as the only B cell-specific component of an isotype switch recombination complex called SWAP. The SWAP complex has specificity for the switch regions upstream of the constant region immunoglobulin genes and it facilitates the transfer of DNA between switch regions. These features suggested that mutations in the gene encoding SWAP-70 might result in humoral...
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