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Article

New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein E.

The Journal of biological chemistry - 19 Oct 2001

Libeu C P, Lund-Katz S, Phillips M C, Wehrli S, Hernáiz M J, Capila I, Linhardt R J, Raffaï R L, Newhouse Y M, Zhou F, Weisgraber K H

Abstract excerpt

Defective binding of apolipoprotein E (apoE) to heparan sulfate proteoglycans (HSPGs) is associated with increased risk of atherosclerosis due to inefficient clearance of lipoprotein remnants by the liver. The interaction of apoE with HSPGs has also been implicated in the pathogenesis of Alzheimer's disease and may play a role in neuronal repair. To identify which residues in the heparin-binding site of apoE and...

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PMID: 11500500
DOI: 10.1074/jbc.M104746200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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