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Article

Biophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemia.

PloS one - 1 Jan 2011

Georgiadou Dimitra, Chroni Angeliki, Vezeridis Alexander, Zannis Vassilis I, Stratikos Efstratios

Abstract excerpt

BACKGROUND: Apolipoprotein E (apoE) is a major protein of the lipoprotein transport system that plays important roles in lipid homeostasis and protection from atherosclerosis. ApoE is characterized by structural plasticity and thermodynamic instability and can undergo significant structural rearrangements as part of its biological function. Mutations in the 136-150 region of the N-terminal domain of apoE, reduce...

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Identifiers

PMID: 22069485
DOI: 10.1371/journal.pone.0027037
PMCID: PMC3206067

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Source receipt: pubmed, retrieved 7 Sept 2026.

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