Article
The functional characteristics of a human apolipoprotein E variant (cysteine at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia.
The Journal of biological chemistry - 25 Jan 1992
Horie Y, Fazio S, Westerlund J R, Weisgraber K H, Rall S C
Abstract excerpt
Type III hyperlipoproteinemia typically is associated with homozygosity for apolipoprotein (apo) E2(Arg158----Cys). Dominant expression of type III hyperlipoproteinemia associated with apoE phenotype E3/3 is caused by heterozygosity for a human apoE variant, apoE3(Cys112----Arg, Arg142----Cys). However, this apoE3 variant was not separable from the normal apoE3 in these patients' plasma because the two proteins...
Topics
- Amino Acid Sequence
- Apolipoproteins E
- Binding Sites
- Binding, Competitive
- Cloning, Molecular
- Cysteine
- Escherichia coli
- Genetic Variation
- Genetic Vectors
- Heparin