Article
Diminished LDL receptor and high heparin binding of apolipoprotein E2 Sendai associated with lipoprotein glomerulopathy.
Journal of the American Society of Nephrology : JASN - 1 Mar 2001
Hoffmann Michael M, Scharnagl Hubert, Panagiotou Eleftheria, Banghard Werner T, Wieland Heinrich, März Winfried
Abstract excerpt
Variants of apolipoprotein E (apoE) have been linked to lipoprotein glomerulopathy, a new glomerular disease characterized by the deposition of lipoproteins in mesangial capillaries. One third of affected patients are heterozygous for apoE2 Sendai (Arg(145) Pro). Variants of apoE can also produce type III hyperlipoproteinemia (HLP). Recessive type III HLP is caused by apoE2 (Arg(158) Cys), a mutant with...
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