Article
Sialic acid moiety of apolipoprotein E3 at Thr(194) affects its interaction with beta-amyloid(1-42) peptides.
Clinica chimica acta; international journal of clinical chemistry - 1 Feb 2008
Sugano Mitsutoshi, Yamauchi Kazuyoshi, Kawasaki Kenji, Tozuka Minoru, Fujita Kiyotaka, Okumura Nobuo, Ota Hiroyoshi
Abstract excerpt
BACKGROUND: The interaction between apolipoprotein (apo) E and beta-amyloid (Abeta) is associated with the development of Alzheimer's disease (AD); however, the details remain unknown. ApoE in cerebrospinal fluid is extensively sialylated, and sialylation of certain proteins are known to modulate biological function. We investigated the effects of a sialic acid moiety of apoE on the apoE-Abeta interaction....
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