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Article

Characterization of the heparin binding sites in human apolipoprotein E.

The Journal of biological chemistry - 25 Apr 2003

Saito Hiroyuki, Dhanasekaran Padmaja, Nguyen David, Baldwin Faye, Weisgraber Karl H, Wehrli Suzanne, Phillips Michael C, Lund-Katz Sissel

Abstract excerpt

Apolipoprotein (apo) E mediates lipoprotein remnant clearance via interaction with cell-surface heparan sulfate proteoglycans. Both the 22-kDa N-terminal domain and 10-kDa C-terminal domain of apoE contain a heparin binding site; the N-terminal site overlaps with the low density lipoprotein receptor binding region and the C-terminal site is undefined. To understand the molecular details of the apoE-heparin...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12588864
DOI: 10.1074/jbc.M213207200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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