Article
Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck.
Cancer research - 15 Jul 1995
Liu T J, el-Naggar A K, McDonnell T J, Steck K D, Wang M, Taylor D L, Clayman G L
Abstract excerpt
Cancer gene therapy strategies for inducing apoptosis in solid tumors may allow contemporary medicine to reassess its management of these cancers. We demonstrated previously that overexpression of the wild-type p53 gene in squamous cell carcinoma of the head and neck cell lines via adenovirus-med...
Topics
- Adenoviridae
- Animals
- Apoptosis
- Carcinoma, Squamous Cell
- Cell Division
- DNA Nucleotidylexotransferase
- DNA, Neoplasm
- DNA, Viral
- Female
- Gene Transfer Techniques
- Genes, Viral
- Genes, p53
- Genetic Therapy
- Head and Neck Neoplasms
- Humans
- Mice
- Mice, Nude
- Mutation
