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Article

Adenovirus-mediated tumor suppressor p53 gene therapy for anaplastic thyroid carcinoma in vitro and in vivo.

The Journal of clinical endocrinology and metabolism - 1 Nov 2000

Nagayama Y, Yokoi H, Takeda K, Hasegawa M, Nishihara E, Namba H, Yamashita S, Niwa M

Abstract excerpt

The present study was designed to evaluate the therapeutic efficacy of adenovirus-mediated wild-type (wt) tumor suppressor p53 expression in four human thyroid carcinoma cell lines harboring p53 mutations (ARO, FRO, NPA, and WRO) and normal human thyroid follicular cells with wt-p53 in vitro and...

Topics

Adenoviridae
Animals
Apoptosis
Carcinoma
Cell Line
Genes, Reporter
Genes, p53
Genetic Therapy
Genetic Vectors
Humans
Male
Mice
Mice, Nude

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Thyroid Gland

Thyroid Neoplasms

Tumor Cells, Cultured

Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 11095436
DOI: 10.1210/jcem.85.11.6941

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11095436-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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