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Article

A Phase I Study of Adenovirus-Mediated Wild-Type <i>p53</i> Gene Transfer in Patients with Advanced Non-Small Cell Lung Cancer

20 Sept 1998

Abstract excerpt

Mutations of the tumor suppressor gene p53 are the most common genetic alterations observed in human cancer. Loss of wild-type p53 function impairs cell cycle arrest as well as repair mechanisms involved in response to DNA damage. Further, apoptotic pathways as induced by radio- or chemotherapy are also abrogated. Gene transfer of wild-type p53 was shown to reverse these deficiencies and to induce apoptosis in...

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Identifiers

PMID: 9759934
DOI: 10.1089/hum.1998.9.14-2075

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