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Article

Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines.

The Journal of biological chemistry - 19 Oct 2001

Akiyama T E, Nicol C J, Fievet C, Staels B, Ward J M, Auwerx J, Lee S S, Gonzalez F J, Peters J M

Abstract excerpt

Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in obesity. Two purebred congenic strains of PPARalpha-null mice were developed to study the role of this receptor in modulating lipid transport and storage. Weight gain and average body weight in wild-type and PPARalpha-null mice on either an Sv/129 or a C57BL/6N background were not markedly...

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Identifiers

PMID: 11495927
DOI: 10.1074/jbc.M107073200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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