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Article

Effects of a high-fat diet and global aryl hydrocarbon receptor deficiency on energy balance and liver retinoid status in male Sprague-Dawley rats.

The Journal of nutritional biochemistry - 1 Sept 2021

Pohjanvirta Raimo, Karppinen Ira, Galbán-Velázquez Suylen, Esteban Javier, Håkansson Helen, Sankari Satu, Lindén Jere

Abstract excerpt

The physiological functions of the aryl hydrocarbon receptor (AHR) are only beginning to unfold. Studies in wildtype and AHR knockout (AHRKO) mice have recently disclosed that AHR activity is required for obesity and steatohepatitis to develop when mice are fed with a high-fat diet (HFD). In addition, a line of AHRKO mouse has been reported to accumulate retinoids in the liver. Whether these are universal...

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Identifiers

PMID: 33965534
DOI: 10.1016/j.jnutbio.2021.108762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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