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Article

Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse.

Molecular systems biology - 1 Jan 2009

Atherton Helen J, Gulston Melanie K, Bailey Nigel J, Cheng Kian-Kai, Zhang Wen, Clarke Kieran, Griffin Julian L

Abstract excerpt

Regulation between the fed and fasted states in mammals is partially controlled by peroxisome proliferator-activated receptor-alpha (PPAR-alpha). Expression of the receptor is high in the liver, heart and skeletal muscle, but decreases with age. A combined (1)H nuclear magnetic resonance (NMR) spectroscopy and gas chromatography-mass spectrometry metabolomic approach has been used to examine metabolism in the...

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Identifiers

PMID: 19357638
DOI: 10.1038/msb.2009.18
PMCID: PMC2683722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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