Article
Phenotype of peroxisome proliferator-activated receptor-alpha(PPARalpha)deficient mice on mixed background fed high fat diet.
Journal of veterinary science - 1 Dec 2003
Kim Bang Hyun, Won Young Suk, Kim Eun-Young, Yoon Mijung, Nam Ki-Taek, Oh Goo Taeg, Kim Dae-Yong
Abstract excerpt
Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-alpha PPARalpha) on obesity. Previous reports demonstrated that PPARalpha is a critical modulator of lipid homeostasis, but the overt, obese phenotypic characterization in the strain of PPAR deficient (PPARalpha-/-) mice is influenced by other factors, including diet and genetics. Therefore, it is necessary to...
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