Article
High level amplification of 1p32-33 and 2p22-24 in small cell lung carcinomas.
International journal of oncology - 1 Sept 2001
Lui W O, Tanenbaum D M, Larsson C
Abstract excerpt
Small cell lung cancer (SCLC) is a frequently occurring, highly aggressive tumor with a generally poor clinical outcome. In order to approach the genetic mechanisms behind the tumor progression, a general screen for DNA copy number alterations was performed using comparative genomic hybridization (CGH). In the series of 23 cases analyzed, CGH alterations were frequently detected ranging from 9 to 22 abnormalities...
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